Too many teams spreads things awfully thin. I was in a spawn league last year for both football and hockey with 19 teams. Playing some pretty obscure folks at times. I'd prefer no larger than 12.
As for the draft, I know it's difficult to get everyone together, but they can always opt to have the computer draft and rank their players. It's not perfect, but it does work pretty well. I've grown to like the two hour live draft approach.
I presume the defending champ is in?
Do you want to go with two flex positions, or just one? I don't see many folks slotting a TE into a flex spot, but if it can be RB/WR then one would be cool, wouldn't it?