(Consider as you read the following that I am a movie fan and not a comic book fan.)
Color me unimpressed. I loved Spidey 2, but the more I know of the new one, the less enthused I am about it. My main concern is that, well, it's just too much. Too many enemies. Too many love interests. Just too much stuff going on, in general, like what happened with the Schumacher Bat-films. It's like everybody knows that this is the last Spidey flick (at least with Tobey), and they're just cramming as much stuff into it as possible.
Was also disappointed to hear about the Sandman/Uncle Ben connection. I don't know how that's supposed to work, exactly, but convoluted stuff like that is one of my main hang-ups with comics. And I've never much cared for the symbiote suit/Venom stuff, either--(and I realize this will sound incredibly silly, so feel free to pick me apart over this) it is just way too comic book-y for my tastes. One of the reasons I loved Spidey 2 so much is Doc Ock--it just felt "real" to me, like that could really happen to somebody, and I don't get that feeling from Sandman or Venom.
I hope I'm wrong, and I'm sure that the action sequences will be amazing (as usual), but I'm just looking less- and less-forward to this.