My question is why couldn't Anakin sense that Padme was pregnant with twins. Apparently he doesn't know that until Return of the Jedi. (Obi-Wan and Yoda seem to share a look too, so I'm wondering if they knew). Shouldn't Jedi be able to sense the babies?
They should have written it different so that Anakin was away for Padme's whole pregnancy, she has the twins just before Grevious' attack, Anakin is recalled to Coruscant (Anakin is excited to see his Wife, but doesn't know about the babies at all...), Padme is evacuated by order of the Jedi and leaves the babies in Obi-Wan's care, but her ship is destroyed in the battle, Anakin comes to blame her death on the Jedi and falls to the darkside (maybe even through in a subplot that instead of trying to save Padme, Sidious seduces Anakin with promises to resurect Padme; "A power some consider, Unnatural....").
Either way Padme's death does seem too weak and out of place for the character and Anakin's fall would have been more believable if it was because of her death, not to prevent it...