The news of 4 villains is definitely interesting, and if true, I hope they pull it off. I've really enjoyed seeing my favorite character on the big screen with Spidey, and I liked both movies a lot, I hope they can continue the quality. I'm curious to see who the "4th villain" is, or if it is some clever play on words that Avi Arad is doing. Lizard would seem like an option with Dr. Connors' appearance Spidey 2, and 1-2 villains could just be touched upon or set up for future installments. I know there were rumors of Mysterio, Electro, and a couple others at one point too, so it will be interesting to see.
In other superhero news, a
recent interview with Jessica Alba again provided further confirmation on the appearance of the Silver Surfer in the next Fantastic Four movie. There is also supposed to be another new villain, in addition to previous reports of Dr. Doom making a comeback. Who knows at this point, further information at the linky. It will be interesting to see how they pull off the Surfer if this is true.