The top ten of the year (so far), according to Box Office Mojo:
1 Star Trek Par. $240,823,706
2 Up BV $229,059,138
3 Monsters Vs. Aliens P/DW $195,536,087
4 X-Men Origins: Wolverine Fox $177,364,794
5 Night at the Museum: Battle of the Smithsonian Fox $157,349,843
6 The Hangover WB $156,628,400
7 Fast and Furious Uni. $154,900,260
8 Paul Blart: Mall Cop Sony $146,336,178
9 Taken Fox $144,977,147
10 Angels & Demons Sony $128,479,731
The current top ten, over a month later:
1 Transformers: Revenge of the Fallen P/DW $382,541,324
2 Up BV $284,578,994
3 Star Trek Par. $254,255,507
4 The Hangover WB $249,808,203
5 Harry Potter and the Half-Blood Prince WB $233,920,753
6 Monsters Vs. Aliens P/DW $197,863,834
7 X-Men Origins: Wolverine Fox $179,556,048
8 Ice Age: Dawn of the Dinosaurs Fox $176,542,789
9 Night at the Museum: Battle of the Smithsonian Fox $173,454,677
10 Fast and Furious Uni. $155,064,265
Hangover made almost another $100m since the last update. Amazing. Good sign for future "adult", R-rated comedies.